Chronic acetylcholinesterase inhibition reduces the effects of physical training on ventricular contractility and coronary bed reactivity in hypertensive rats
Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics
Abstract Soft bioelectronic devices exhibit motion-adaptive properties for neural interfaces to investigate complex neural circuits. Here, we develop a fabrication approach through the control of metamorphic polymers’ amorphous-crystalline t…
In Vivo Base Editing of <i>Scn5a</i> Rescues Type 3 Long QT Syndrome in Mice
BACKGROUND: Pathogenic variants in SCN5A can result in long QT syndrome type 3, a life-threatening genetic disease. Adenine base editors can convert targeted A T base pairs to G C base pairs, offering a p…
Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration
Abstract Background and Purpose Diseases of raised intracranial pressure (ICP) cause severe morbidity and mortality. Multiple drugs are utilised to lower ICP including acetazolamide and topiramate. However, the evidence for their use is unclear. We aimed to…
DOI: 10.1111/bph.16213
Intestinal neuropod cell GUCY2C regulates visceral pain
DOI: 10.1172/jci165578
Liquid crystal elastomer based dynamic device for urethral support: Potential treatment for stress urinary incontinence
Broadening the clinical spectrum: molecular mechanisms and new phenotypes of <i>ANO3</i>-dystonia
Abstract Anoctamin 3 (ANO3) belongs to a family of transmembrane proteins that form phospholipid scramblases and ion channels. A large number of ANO3 variants were identified as the cause of craniocervical dystonia, but the underlying pathogeni…
Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs
Abstract Aims Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches are required to predict cardiotoxicity with high specificity and sensitivity. Ideal…
DOI: 10.1093/cvr/cvad141
Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin
Abstract Aims Obesity is an epidemic that is a critical contributor to hypertension and other cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase (eNOS/NOS3) in…
DOI: 10.1093/cvr/cvad164
Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening
Abstract Direct modulation of cardiac myosin function has emerged as a therapeutic target for both heart disease and heart failure. However, the development of myosin-based therapeutics has been hampered by the lack of targeted in vitro screening assays. In t…