Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites
Hybrid assembly of polymeric nanofiber network for robust and electronically conductive hydrogels
Abstract Electroconductive hydrogels have been applied in implantable bioelectronics, tissue engineering platforms, soft actuators, and other emerging technologies. However, achieving high conductivity and mechanical rob…
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential
Abstract Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT 2A receptor activation mediates psychedelic effects, prototypical psychedelics activate…
In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals
Injectable tissue prosthesis for instantaneous closed-loop rehabilitation
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy
Abstract Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves 1,2 . Although the o…
Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury
Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on electrically triggered CSDs in healthy and brain-injured animals. Rats received eit…
Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function
Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient match…
NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling
DOI: 10.1172/jci152071
Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation
Abstract Spreading depolarization (SD), the underlying mechanism of migraine aura, may trigger the opening of the pannexin 1 (PANX1) pore to sustain the cortical neuroinflammatory cascades involved in the genesis of headache. Yet, the mechan…