Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function
Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient match…
NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling
DOI: 10.1172/jci152071
Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation
Abstract Spreading depolarization (SD), the underlying mechanism of migraine aura, may trigger the opening of the pannexin 1 (PANX1) pore to sustain the cortical neuroinflammatory cascades involved in the genesis of headache. Yet, the mechan…
Nitric Oxide Modulates Ca <sup>2+</sup> Leak and Arrhythmias via S-Nitrosylation of CaMKII
BACKGROUND: Nitric oxide (NO) has been identified as a signaling molecule generated during β-adrenergic receptor stimulation in the heart. Furthermore, a role for NO in triggering spontaneous Ca…
Porous liquid metal–elastomer composites with high leakage resistance and antimicrobial property for skin-interfaced bioelectronics
Liquid metal–elastomer composite is a promising soft conductor for skin-interfaced bioelectronics, soft robots, and others due to its large stretchability, ultrasoftness, high electrical conductivity, and mechanical-electrical decoupling. However, it often suf…
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human PAEC with…
Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling
Aortic stenosis (AS) affects about 1.5 million people in the United States and is associated with a 5-year survival rate of 20% if untreated. In these patients, aortic valve replacement is performed to restore adequate hemodynamics and alleviate symptoms. The…
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
SVEP1 is an endogenous ligand for the orphan receptor PEAR1
Abstract Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes vascular disease and associates with platelet reactivity in humans. Here, using a human gen…
Targeted Delivery of Apoptotic Cell‐Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation
Abstract The modulation of inflammatory responses plays an important role in the pathobiology of cardiac failure. In a natural healing process, the ingestion of apoptotic cells and their apoptotic bodies by macrophages in a focal lesion result in resolution o…