A minimally invasive thrombotic model to study stroke in awake mice
Effects of Hormone Replacement Treatment with Estrogen and Progestins on the Vascular Renin–Angiotensin System of Ovariectomized Rats
The renin–angiotensin system (RAS) is the main endocrine and tissular component responsible for controlling cardiovascular homeostasis, which can be modulated by estrogen levels. This study investigated the effects of hormone treatments with estrogen and proge…
DOI: 10.3390/ijms26104930
Fibronectin in the olfactory mucus increases sensitivity of olfactory receptor response to odorants
Olfaction is a highly sensitive chemical detection system, but the origins of this sensitivity remain poorly understood. In terrestrial vertebrates, inhaled odorants diffuse through olfactory epithelial mucus (OEM) before activating olfactory receptors (ORs) o…
B cells promote atrial fibrillation via autoantibodies
A neuronal architecture underlying autonomic dysreflexia
Control of spatiotemporal activation of organ-specific fibers in the swine vagus nerve by intermittent interferential current stimulation
Vagus nerve stimulation (VNS) is emerging as potential treatment for several chronic diseases. However, limited control of fiber activation, e.g., to promote desired effects over side effects, restricts clinical translation. Towards that goal, we describe a VN…
Dual and plasticity-dependent regulation of cerebello-zona incerta circuits on anxiety-like behaviors
Clinical observation has identified cerebellar cognitive affective syndrome, which is characterized by various non-motor dysfunctions such as social disorders and anxiety. Increasing evidence has revealed reciprocal mono-/poly-synaptic connections of cerebello…
A programmable and self-adaptive ultrasonic wireless implant for personalized chronic pain management
Chronic pain management typically involves opioids, which are associated with severe side effects such as addiction. Implantable percutaneous electrical stimulators are a promising alternative approach to pain management. However, they are expensive, can cause…
Chronic circadian disruption alters cardiac function and glucose regulation in mice
Cardiometabolic disease is a leading cause of death worldwide. One factor that may contribute to the risk, onset, and severity of symptoms is disrupted circadian rhythms. Our study uses two strains of mice to further elucidate this relationship: healthy contro…
Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice
Skeletal muscle undergoes many alterations with aging. However, the impact of aging on muscle’s ability to secrete myokines and its subsequent effects on the body remain largely unexplored. Here, we identify myokines that have the potential to ameliorate age-r…