Dose-related systemic and cerebral hemodynamic effects of norepinephrine in newborn piglets with hypoxia-reoxygenation
Force overestimation during vascular occlusion is triggered by motor system inhibition
Gestational high-sucrose diet mediated vascular hyper-contractility in mesenteric arteries from offspring
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Abstract Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA…
HCN4 channels sense temperature and determine heart rate responses to heat
Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies
Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy
Abstract Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergot…
Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming
Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation
Abstract In patients with congenital heart disease, the development of pulmonary arterial hypertension (PAH) is based on vascular exposure to abnormal hemodynamic forces. In our work using a large animal model of increased pulmonary blood fl…