Millimetre-scale bioresorbable optoelectronic systems for electrotherapy
Modulation of Sel1L can alleviate altered ER homeostasis towards white matter damage in CKD-stroke complex
Morphological and functional decline of the SNc in a model of progressive parkinsonism
Abstract The motor symptoms of Parkinson’s Disease are attributed to the degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Previous work in the MCI-Park mouse model has suggested that the loss of somatodendritic dopamine…
Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition
Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice
Abstract The prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, while treatment options are inadequate. Hypertension and obesity-related metabolic dysfunction contribute to HFpEF. Nitro-oleic acid (NO2-OA) impacts me…
Optimising CPAP and oxygen levels to support spontaneous breathing in preterm rabbits
Abstract Background Very preterm infants often require respiratory support after birth with current recommendations suggesting the use of continuous positive airway pressure (C…
Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation
Increased cardiac excitability and reduced electrical coupling promote cardiac arrhythmia and can be quantified by input resistance ( R m ), pacing threshold ( I…
Pharmacologic and endotoxic reprogramming of renal vasodilatory, inflammatory, and apoptotic blemishes in weaning preeclamptic rats
Abstract Preeclampsia (PE) and peripartum sepsis are two complications of pregnancy and are often associated with disturbed renal function due possibly to dysregulated renin angiotensin system. Here we evaluated hemodynamic and renal consequences of…
Piezoelectric nanofiber–based intelligent hearing system
Hearing loss, affecting individuals of all ages, can impair education, social function, and quality of life. Current treatments, such as hearing aids and implants, aim to mitigate these effects but often fall short in addressing the critical issue of accuratel…