cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling
Fluid shear stress (FSS) from blood flow sensed by vascular endothelial cells (ECs) determines vessel behavior, but regulatory mechanisms are only partially understood. We used cell state transition assessment and regulation (cSTAR), a powerful computational m…
Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment
Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelator…
Differential encoding of mammalian proprioception by voltage-gated sodium channels
Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of…
Dose-related systemic and cerebral hemodynamic effects of norepinephrine in newborn piglets with hypoxia-reoxygenation
Force overestimation during vascular occlusion is triggered by motor system inhibition
Gestational high-sucrose diet mediated vascular hyper-contractility in mesenteric arteries from offspring
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Abstract Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA…
HCN4 channels sense temperature and determine heart rate responses to heat
Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies
Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy
Abstract Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergot…