Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia
Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice
Abstract Cannabidiol (CBD), a nonpsychoactive compound from Cannabis , has various bioactive functions in humans and animals. Evidence suggests that CBD promotes muscle injury reco…
Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine
Abstract It is unclear whether hallucinogenic tryptamine derivatives namely N , N -dimethyl-tryptamine (DMT) and 5-methoxy-…
Cardiac parasympathetic denervation reduces hypoxic tachycardia, baroreflex sensitivity and heart rate variability in humans
CaV2.3 channels in the mouse central medial thalamic nucleus are essential for thalamocortical oscillations and spike wave discharges
Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors
Cholesterol metabolism and neuroinflammatory changes in a non-human primate spinal nerve ligation model
cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling
Fluid shear stress (FSS) from blood flow sensed by vascular endothelial cells (ECs) determines vessel behavior, but regulatory mechanisms are only partially understood. We used cell state transition assessment and regulation (cSTAR), a powerful computational m…
Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment
Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelator…
Differential encoding of mammalian proprioception by voltage-gated sodium channels
Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of…