Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale
Abstract The advent of neuroimaging has increased our understanding of brain function. While most brain-wide functional imaging modalities exploit neurovascular coupling to map brain activity at millimeter resolutions, the recording of funct…
Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells
Glutamate drives ‘local Ca2+ release’ in cardiac pacemaker cells
Abstract The sinoatrial node (SAN) is the origin of the electrical signals for rhythmic heartbeats in mammals. The spontaneous firing of SAN pacemaker cells (SANPCs) triggers cardiac contraction. ‘Local Ca…
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hypertension, inflammation, and placental dysfunction. Gut microbiota plays key roles in inflammation and hypertension. Howev…
Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types
In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts
Background: Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized that large-sca…
Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure
Abstract Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgen…
Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
Abstract Potassium (K+) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K+channel KCNB1 (Kv2.1) in…
Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing
Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in…
Lean body mass and the cardiovascular system constitute a female-specific relationship
Recent evidence points toward a link between lean body mass (LBM) and cardiovascular capacity in women. This study aimed at determining the sex-specific relationship of LBM with central and peripheral circulatory variables in healthy women and men (…