Recording of intracranial pressure in conscious rats via telemetry
Although cerebral perfusion pressure (CPP) is known to be fundamental in the control of normal brain function, there have been no previous long-term measurements in animal models. The aim of this study was to explore the stability and viability of long-term re…
Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats
Expansion of physiological knowledge increasingly requires examination of processes in the normal, conscious state. The current study describes a novel approach combining surgical implantation of radio-telemeters with vascular access ports (VAPs) to allow repe…
Chronic intermittent hypoxia reshapes circadian metabolic architecture in a model of sleep apnea
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (IH) during sleep, is increasingly recognized as a driver of metabolic dysfunction. However, its impact on circadian metabolic regulation remains poorly understood. Here, we investiga…
Effects of crank length on the cardiovascular response in a rat model of motorized cycling
Study Design: Longitudinal pre-clinical study.Objectives: To determine the impact of crank length and cadence on pedal reaction forces and cardiovascular responses in a preclinical model of high thoracic severe spinal cord injury.Setting: The Kentucky Spinal C…
Distributed battery-free bioelectronic implants with improved network power transfer efficiency via magnetoelectrics
Networks of miniature implants could enable simultaneous sensing and stimulation at different locations in the body, such as the heart and central or peripheral nervous system. This capability would support precise disease tracking and treatment or enable pros…
Cardiogenic control of affective behavioural state
Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart. However, whether an increased heart rate might itself induce anxiety or fear responses is unclear. Physiological theories…
A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses
Exercise including locomotion requires appropriate autonomic cardiovascular adjustments to meet the metabolic demands of contracting muscles, yet the functional brain architecture underlying these adjustments remains unknown. Here, we demonstrate brainstem cir…
A method to evaluate dynamic cerebral pressure-flow relationships in the conscious rat.
The classic dogma of cerebral autoregulation is that cerebral blood flow is steadily maintained across a wide range of perfusion pressures. This has been challenged by recent studies suggesting little to no 'autoregulatory plateau' in the relationship between…
Noninvasive Neuroprosthesis Promotes Cardiovascular Recovery After Spinal Cord Injury
Spinal cord injury (SCI) leads to severe impairment in cardiovascular control, commonly manifested as a rapid, uncontrolled rise in blood pressure triggered by peripheral stimuli—a condition called autonomic dysreflexia. The objective was to demonstrate the tr…
DOI: s13311-021-01034-5
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
Abstract Spinal cord injury (SCI) induces haemodynamic instability that threatens survival1,2,3, impairs neurological recovery4,5, increases the risk of cardiovascular disease6,7, and reduces quality of life8,9. Haemodynamic instability in this context is due…