Theory of hierarchically organized neuronal oscillator dynamics that mediate rodent rhythmic whisking
Three-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming
Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac regeneration. Full chemical reprogramming with small molecules to generate cardiomyocytes may be more amenable than genetic reprogramming for clinical applications as it a…
Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts
Abstract The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely understood. Previously, we showed that the ICD-bound transmembrane protein 65 (Tmem65) was re…
Touch IoT enabled by wireless self-sensing and haptic-reproducing electronic skin
Tactile sensations are mainly transmitted to each other by physical touch. Wireless touch perception could be a revolution for us to interact with the world. Here, we report a wireless self-sensing and haptic-reproducing electronic skin (e-skin) to realize non…
Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics
Abstract Many ultrafast phenomena in biology and physics are fundamental to our scientific understanding but have not yet been visualized owing to the extreme speed and sensitivity requirements in imaging modalities. Two examples are the propagation of passiv…
Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotyp…
Association of incremental pulse wave velocity with cardiometabolic risk factors
Abstract We investigate the association of incremental pulse wave velocity (ΔC; the change in pulse wave velocity over a cardiac cycle) with cardiometabolic risk factors and report the first and (currently) the largest population-level data.…
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling
Abstract Acute myocardial infarction is a common condition responsible for heart failure and sudden death. Here, we show that following acute myocardial infarction in mice, CD8 + T…
Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia
Abstract Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial…
Loss of CASK Accelerates Heart Failure Development
Rationale: Increased myocardial activity of CaMKII (Ca/calmodulin-dependent kinase II) leads to heart failure and arrhythmias. In Drosophila neurons, interaction of CaMKII with CASK (Ca/CaM-dependent seri…