Non-invasive recording from the human olfactory bulb
Abstract Current non-invasive neuroimaging methods can assess neural activity in all areas of the human brain but the olfactory bulb (OB). The OB has been suggested to fulfill a role comparable to that of V1 and the thalamus in the visual sy…
Phosphodiesterase 3A and Arterial Hypertension
Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke…
Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence
Summary Objective Medication nonadherence directly contributes to poor seizure control. A lack of emphasis on correcting poor adherence and failures in patient adherence can result in unwarranted alterations to a patient's drug regimen. We have modeled nonad…
DOI: 10.1111/epi.14655
Hypertensive Response to Ischemic Stroke in the Normotensive Wistar Rat
Background and Purpose— Over 80% of ischemic stroke patients show an abrupt increase in arterial blood pressure in the hours and days following ischemic stroke. Whether this poststroke hypertension is beneficial or harmful remains controversial an…
Nitrosative stress drives heart failure with preserved ejection fraction
Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
Abstract Heart rate is under the precise control of the autonomic nervous system. However, the wiring of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop a clearing-imaging-analysis pipeline to visua…
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
Abstract Oxidative stress plays an important role in the pathogenesis of many disease states. In the heart, reactive oxygen species are linked with cardiac ischemia/reperfusion injury, hypertrophy, and heart failure. While this correlation between ROS and car…
Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
Abstract Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing…