Single-source PPG-based local pulse wave velocity measurement: a potential cuffless blood pressure estimation technique
Abstract Objective: A novel photoplethysmograph probe employing dual photodiodes excited using a single infrared light source was developed for local pulse wave velocity (PWV) measurement. The potenti…
A Magnetic Plethysmograph Probe for Local Pulse Wave Velocity Measurement
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Abstract Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO 2 and pH homeostasis in the brain. CO 2…
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
Abstract Shrm4, a protein expressed only in polarized tissues, is encoded by theKIAA1202gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we rep…
DOI: 10.1038/ncomms14536
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Abstract Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain <25% of SQTS cases. Here we identify a missense mutation in the ani…
Mammalian γ2 AMPK regulates intrinsic heart rate
Abstract AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding ade…
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
Abstract The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connect…
DOI: 10.1038/ncomms13035
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
Abstract Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly understood, which contributes t…
DOI: 10.1038/ncomms11303
Cardioprotection and lifespan extension by the natural polyamine spermidine
DOI: 10.1038/nm.4222
Fish optimize sensing and respiration during undulatory swimming
Abstract Previous work in fishes considers undulation as a means of propulsion without addressing how it may affect other functions such as sensing and respiration. Here we show that undulation can optimize propulsion, flow sensing and respiration concurrentl…
DOI: 10.1038/ncomms11044