Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models
Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy
DOI: 10.1172/jci158897
Manganese-driven CoQ deficiency
Abstract Overexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthes…
Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life
Abstract Obesity is a pre-disposing condition for chronic obstructive pulmonary disease, asthma, and pulmonary arterial hypertension. Accumulating evidence suggests that metabolic influences during development can determine chronic lung dise…
Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase
Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell–endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver o…