Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms
Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control
Abstract Spinal cord injury chronically alters cardiac structure and function and is associated with increased odds for cardiovascular disease. Here, we investigate the cardiac consequences of spinal cord injury on the acute-to-chronic continuum, and the cont…
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration
Abstract Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mechanism of action of…
The cephalic phase of insulin release is modulated by IL-1β
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure
Abstract Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy. Here, we show that the right ventricle predominantly e…
The endocannabinoid anandamide is an airway relaxant in health and disease
Abstract Chronic obstructive airway diseases are a global medical burden that is expected to increase in the near future. However, the underlying mechanistic processes are poorly understood so far. Herein, we show that the endocannabinoid anandamide (AEA) ind…
The impact of obesity-related raised intracranial pressure in rodents
Abstract Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis in disorders such as idiopathic intracranial pressure (IIH). We investigated the effect of diet induced obesity (D…
The neurons that restore walking after paralysis
Abstract A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the l…
The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis
Abstract Sarcoplasmic/endoplasmic reticulum calcium ATPase SERCA2 mediates calcium re-uptake from the cytosol into sarcoplasmic reticulum, and its dysfunction is a hallmark of heart failure. Multiple factors have been identified to modulate SERCA2 activity, h…
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine production. The zinc finger protein 36 (ZFP36) family genes ( Zfp36 , Zfp36l1 , and Zfp36l2…